Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models

Havel, Václav, Kruegel, Andrew C., Bechand, Benjamin, McIntosh, Scot, Sames, Dalibor, Javitch, Jonathan A., Majumdar, Susruta · 2024 · Nature Communications

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BREAKTHROUGH: Oxa-iboga alkaloids (benzofuran-containing) lack proarrhythmic effects of ibogaine/noribogaine, show superior efficacy in OUD models. Potent KOR agonists with single-dose efficacy.

Safety data present: HERG