Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Addiction States

Havel, Václav, Kruegel, Andrew C., Bechand, Benjamin, McIntosh, Scot, Stallings, Leia, Hodges, Alana, Wulf, Madalee G., Nelson, Melissa, Hunkele, Amanda, Ansonoff, Mike, Pintar, John E., Hwu, Christopher, Abi-Gerges, Najah, Zaidi, Saheem A., Katritch, Vsevolod, Yang, Mu, Javitch, Jonathan A., Majumdar, Susruta, Hemby, Scott E., Sames, Dalibor · 2021 · bioRxiv

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Columbia/Sames lab oxa-iboga alkaloids: synthetic variants maintain anti-addictive efficacy while reducing cardiac liability. Novel class development for safer analogues.

Safety data present: HERG