Development of Bioisosteric Iboga-alkaloids as Antinociceptive and Anxiolytic Agents with Neuroprotective Effects

Gupta, Abhishek, Bhattacharya, Tuhin, Pratihar, Subhamoy, Parvage, Sabnur, Sharma, Swrajit Nath, Sarkar, Arnab, De, Akash, Karmakar, Sanmoy, Dey, Sanjit, Sinha, Surajit · 2025 · Preprint

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Benzofuran iboga analogues (C2, C4) show antinociceptive/anxiolytic effects with improved cardiac safety. C4 showed no QTc prolongation in rat ECG. Bioisosteric replacement of indole reduces hERG blockade. BDNF/GABA/dopamine elevation.

Safety data present: QTC, HERG