Ibogaine Acute Administration in Rats Promotes Wakefulness, Long-Lasting REM Sleep Suppression, and a Distinctive Motor Profile

González, Joaquín, Prieto, José P., Rodríguez, Paola, Cavelli, Matías, Benedetto, Luciana, Mondino, Alejandra, Pazos, Mariana, Seoane, Gustavo, Carrera, Ignacio, Scorza, Cecilia, Torterolo, Pablo · 2018 · Frontiers in Pharmacology

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Sleep architecture: Ibogaine promotes wakefulness, robust long-lasting REM suppression, dose-dependent motor profile (tremor, flat posture at high dose). No head-shake (5HT2A marker). Uruguay polysomnography.

Dosing: 20–40 mg/kg i.p. ibogaine (rat) (intraperitoneal)