Influence of CYP2D6 Activity on the Pharmacokinetics and Pharmacodynamics of a Single 20 mg Dose of Ibogaine in Healthy Volunteers

Glue, Paul, Winter, Helen, Garbe, Kira, Jakobi, Hannah, Lyudin, Alexander, Lenagh-Glue, Zoe, Hung, C. Tak · 2015 · The Journal of Clinical Pharmacology

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CYP2D6 CRITICAL: Paroxetine pretreatment (CYP2D6 inhibition) doubled active moiety exposure. Recommends genotyping + halved doses for CYP2D6 poor metabolisers. 20mg safe in healthy volunteers.

Dosing: 20 mg oral ibogaine (human) (oral)

Sample size: 21