Development of Novel Medications for Drug Addiction: The Legacy of an African Shrub

Glick, Stanley D., Maisonneuve, Isabelle M. · 2000 · Annals of the New York Academy of Sciences

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18-MC matches ibogaine anti-addictive efficacy across morphine, cocaine, alcohol, nicotine without tremor or bradycardia. Downward shift in dose-response suggests reduced reinforcing efficacy.

Dosing: 20–40 mg/kg i.p. (rats); ibogaine 40–100 mg/kg (intraperitoneal)