18-Methoxycoronaridine (18-MC) and Ibogaine: Comparison of Antiaddictive Efficacy, Toxicity, and Mechanisms of Action
Mechanisms Review high
AI-extracted · unverified · confirm at source
18-MC vs ibogaine comparison: equal anti-addictive efficacy for morphine, cocaine, alcohol, nicotine. 18-MC lacks tremor, cerebellar damage, bradycardia. Lower NMDA/sigma-2 affinity. Greater therapeutic index than ibogaine.
Dosing: 10–40 mg/kg i.p. (rats); ibogaine 40–100 mg/kg (intraperitoneal)