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Effects and aftereffects of ibogaine on morphine self-administration in rats

Glick, Stanley D., Rossman, Kenner, Steindorf, Samara, Maisonneuve, Isabelle M., Carlson, John N. · 1991 · European Journal of Pharmacology

Outcomes Preclinical moderate

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Ibogaine (2.5–80 mg/kg i.p.; threshold 10 mg/kg) dose-dependently reduced morphine self-administration in rats acutely and ≥1 day post-dose; persistent decreases over weeks in some rats. Aftereffect not from conditioned aversion or motor impairment.

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