Increased cortical thickness and decreased brain age among special operations veterans with blast TBI after a magnesium-ibogaine protocol

Geoly, Andrew D., Coetzee, John P., Buchanan, Derrick Matthew, Struckmann, Wiebke, Kim, Bora, Sridhar, Malvika, Azeez, Azeezat, Lissemore, Jennifer I., Cherian, Kirsten, Faerman, Afik, Keynan, Jackob N., Singal, Prakamya, Shanbour, Alaa, Bandeira, Igor D., Kratter, Ian H., Adamson, Maheen M., Saggar, Manish, Rolle, Cammie, Williams, Nolan R. · 2026 · iScience

AI-extracted · unverified · confirm at source

MISTIC therapy associated with increased cortical thickness in 13 regions, subcortical expansion in 8 regions, and predicted brain age reduction of 1.3 years at 1 month in SOF veterans with blast TBI (n=25)

Dosing: 12.05 mg/kg (SD 1.44) oral ibogaine HCl with IV magnesium sulfate (1 mg pre- and post-ibogaine) (oral)

Sample size: 25

Contraindications: Pre-existing cardiac disease (QT prolongation risk with ibogaine), Drug-drug interactions (QT-prolonging medications), Pre-existing medical conditions associated with ibogaine fatalities, Overdose risk