Deconstructing the Iboga Alkaloid Skeleton: Potentiation of FGF2-induced Glial Cell Line-Derived Neurotrophic Factor Release by a Novel Compound

Gassaway, Madalee M., Jacques, Teresa L., Kruegel, Andrew C., Karpowicz, Richard J. Jr., Li, Xiaoguang, Li, Shu, Myer, Yves, Sames, Dalibor · 2015 · ACS Chemical Biology

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Novel acyclic iboga analogue XL-008 potentiates FGF2-induced GDNF release >2-fold potency and >3-fold efficacy in C6 glioma cells via MEK/PI3K pathways. Sames lab, Columbia.