Effects of ibogaine on naloxone-precipitated withdrawal in morphine-dependent mice

Francés, Bernard, Gout, R., Cros, J., Zajac, Jean-Marie · 1992 · Fundamental & Clinical Pharmacology

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Ibogaine (30 mg/kg IP) failed to attenuate morphine withdrawal in mice and significantly potentiated naloxone-precipitated jumping (~9-fold), suggesting amplification of opioid-mediated responses rather than anti-withdrawal activity.

Dosing: 30 mg/kg IP (ibogaine in saline) (intraperitoneal)