The psychoactive compound ibogaine sex-dependently alters the firing rate and afterhyperpolarization of Ih-negative neurons in the mouse ventral tegmental area

Eliasen, Jannik Nicklas, Rezagholizadeh, Amir, Jacobsen, Helene Påbøl, Kristiansen, Uffe, Kohlmeier, Kristi A. · 2025 · Neuroscience

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Sex-dependent effects: ibogaine (100μM) decreased AP firing in male VTA GABAergic neurons but not females; altered female AHP kinetics; no membrane current changes; intracellular Ca²⁺ rises in both sexes

Sample size: 30