Study of the Acute Toxicity of the Aqueous Extract of Tabernanthe iboga (Baill.) (Apocynacea) on Wistar Rats

Mayindza Ekaghba, E. L., Boukandou Mounanga, M. M., Mathouet, H., Mendene, H. F., Mba Ndong, J. G. · 2020 · Asian Journal of Science and Technology

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Aqueous T. iboga root bark extract LD50=1442.6 mg/kg oral in Wistar rats, classifying whole extract as low toxicity (Hodge-Sterner). First LD50 study of total Gabonese iboga extract.

Dosing: LD50=1442.6 mg/kg; LD0=784.71 mg/kg; LD100=2000 mg/kg (aqueous root bark extract, oral, Wistar rats) (oral)