Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies

Darlene C. Deecher, Milton Teitler, David M. Soderlund, William G. Bornmann, Martin E. Kuehne, Stanley D. Glick · 1992 · Brain Research

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Ibogaine binds κ-opioid receptors (Ki=2.08 μM) but not μ or δ via [³H]carfentanil; binding is reversible. Ibogaine and harmaline congeners interact with voltage-dependent sodium channels (μM range). No GABA interaction found.