Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport

Coleman, Jonathan A., Yang, Dongxue, Zhao, Zhiyu, Wen, Po-Chao, Yoshioka, Craig, Tajkhorshid, Emad, Gouaux, Eric · 2019 · Nature

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NATURE LANDMARK: First cryo-EM SERT-ibogaine structures showing outward-open, occluded, inward-open conformations. Defines transport mechanism and ibogaine non-competitive inhibition at molecular level.