Remission of Severe Opioid Use Disorder with Ibogaine: A Case Report

Cloutier-Gill, Laurie, Wood, Evan, Millar, Trevor, Ferris, Caroline, Socias, M. Eugenia · 2016 · Journal of Psychoactive Drugs

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Treatment-refractory OUD patient (19yr history) achieved 18-month abstinence after 4-day ibogaine HCl treatment (32 mg/kg total). Mild bradycardia observed (51–67 bpm). Patient attributed success to transformative experience over withdrawal relief.

Dosing: 2300 mg (32 mg/kg) ibogaine HCl total, 4-day protocol (test doses up to 2.5 mg/kg, flood up to 20 mg/kg, boosters 5 mg/kg/day) (oral)

Sample size: 1

Contraindications: Pre-existing cardiovascular disease, Concurrent QTc-prolonging substances, Electrolyte imbalances (hypokalemia)