Magnesium–ibogaine therapy in veterans with traumatic brain injuries

Cherian, Kirsten N., Faerman, Afik, Brown, Randi E., Shamma, Ahmed, Keynan, Or, Coetzee, John P., Phillips, Angela, Bassano, Nicholas J., Sahlem, Gregory L., Inzunza, Jose, Millar, Trevor, Dickinson, Jonathan, Rolle, C. E., Keller, Jennifer, Adamson, Maheen, Williams, Nolan R. · 2024 · Nature Medicine

AI-extracted · unverified · confirm at source

MISTIC (Nature Medicine), n=30 SOF Veterans/TBI. Effect sizes: WHODAS d=2.20, PTSD d=2.54, Depression d=2.80, Anxiety d=2.13. Mg+Ibo prevented all QTc prolongation. No SAEs.

Dosing: 11.3–14.7 mg/kg ibogaine (mean 12.1 mg/kg) (oral)

Sample size: 30

Safety data present: QTC, ELECTROLYTE

Contraindications: Pre-existing cardiac conditions, QT-prolonging medications, Active substance withdrawal