Ibogaine Block of the NMDA Receptor: In Vitro and In Vivo Studies

Chen, Kang, Kokate, Tushar G., Donevan, Sean D., Carroll, F. Ivy, Rogawski, Michael A. · 1996 · Neuropharmacology

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Ibogaine is an open channel NMDA receptor antagonist (IC₅₀ 3.1 µM, -60 mV). Block is use- and voltage-dependent, occluded by Mg²⁺. In vivo MES protection ED₅₀ 31 mg/kg i.p.; LD₅₀ 213 mg/kg in mice.