Noribogaine acute administration in rats promotes wakefulness and suppresses REM sleep

Castro-Nin, Juan Pedro, Serantes, Diego, Rodriguez, Paola, Gonzalez, Bruno, Carrera, Ignacio, Torterolo, Pablo, González, Joaquín · 2024 · Psychopharmacology

AI-extracted · unverified · confirm at source

Noribogaine promotes wakefulness, reduces SWS, and profoundly suppresses REM sleep in rats (20 and 40 mg/kg IP). Effects stronger than ibogaine, implicating SERT blockade as the shared mechanism.

Dosing: 20 and 40 mg/kg IP (noribogaine·HCl in warm degassed saline) (intraperitoneal)