Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration

Carnicella, Sebastien, He, Dao-Yao, Yowell, Quinn V., Glick, Stanley D., Ron, Dorit · 2010 · Addiction Biology

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Noribogaine increases GDNF expression like ibogaine; 18-MC does not. Intra-VTA noribogaine reduces alcohol self-administration; 18-MC does not. Different mechanisms despite similar anti-addictive profiles. Key for analogue development.

Dosing: 5–50 µM (cell culture); 0.5–4 µg/µl intra-VTA (rats) (not-specified)