Neurorestorative Properties of Ibogaine: Linking Multi-Receptor Affinities to Remyelination and Metabolic Restoration

Calvey, Tanya, Govender, Demi, Owen, Gavin, Tumba, Nancy, Lang, Dirk, Lerer, Bernard, Stein, Dan J, Shoptaw, Steven · 2026 · Acta Neuropsychiatrica

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Proposes ibogaine's multi-receptor affinities (kappa opioid, NMDA, sigma-2) facilitate remyelination and metabolic restoration, providing mechanistic rationale for treating OUD, MS, and TBI via white matter repair

Contraindications: Pre-existing cardiac conditions, CYP2D6 drug interactions, Polydrug use, Concurrent methadone or benzodiazepine use, Undiagnosed cardiovascular disease, Potassium and magnesium abnormalities