A review of the mechanisms involved in the neuroprotection and neurotoxicity of Iboga alkaloids
Mechanisms Review moderate
AI-extracted · unverified · confirm at source
Dual neuroprotective/neurotoxic review from Gabon (IPHAMETRA/CENAREST). Crude extract LD₅₀ = 1442.571 mg/kg oral; ibogaine LD₅₀ = 263–327 mg/kg; noribogaine LD₅₀ = 630 mg/kg. σ₂ receptor affinity correlates with neurotoxicity.