Application of Electrophysiological Method to Study Interactions between Ibogaine and Cocaine

Binienda, Zbigniew, Beaudoin, Michael A., Thorn, Brett T., Sadovova, Natalya, Skinner, Robert D., Slikker, William Jr., Ali, Syed F. · 2000 · Annals of the New York Academy of Sciences

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ELECTROPHYSIOLOGY: IBO pretreatment (50mg/kg, 1h prior) dramatically altered cocaine ECoG response - increased delta/theta/alpha1 power vs cocaine alone. DA levels decreased further with IBO/COC combination. Suggests decreased cocaine response.

Dosing: 50 mg/kg ibogaine (rat i.p.); 20 mg/kg cocaine (rat i.p.) (intraperitoneal)