Neurochemical and Behavioural Interactions Between Ibogaine and Nicotine in the Rat
Mechanisms Preclinical moderate
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Ibogaine (40 mg/kg IP) attenuated nicotine-induced NAc dopamine overflow 22h post-treatment but not locomotion; produced long-lasting anxiogenesis and mPFC neurochemical changes persisting ≥7 days
Dosing: 40 mg/kg IP (ibogaine in 25% ethanol/sterile water, 1.0 ml/kg) (intraperitoneal)