Ibogaine and addiction in the animal model, a systematic review and meta-analysis

Belgers, M., Leenaars, M., Homberg, J. R., Ritskes-Hoitinga, M., Schellekens, A. F. A., Hooijmans, C. R. · 2016 · Translational Psychiatry

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SYRCLE META-ANALYSIS: 27 studies show ibogaine reduces drug self-administration especially in first 24h. No effect on CPP. Motor impairment and cerebellar toxicity noted. Warrants clinical trials with monitoring.

Dosing: Animal: low 0–40 mg/kg, medium 40–80 mg/kg, high >80 mg/kg (mostly i.p.); human equivalent 10–25 mg/kg oral (not-applicable)