In Vivo Neurobiological Effects of Ibogaine and Its O-Desmethyl Metabolite, 12-Hydroxyibogamine (Noribogaine), in Rats

Baumann, Michael H., Rothman, Richard B., Pablo, John P., Mash, Deborah C. · 2001 · Journal of Pharmacology and Experimental Therapeutics

AI-extracted · unverified · confirm at source

Noribogaine is ~10× more potent than ibogaine as indirect 5-HT agonist via SERT inhibition. Ibogaine causes tremors/ataxia; noribogaine does not. Neither drug alters accumbens DA. Noribogaine may be safer alternative.

Dosing: 1–10 mg/kg i.v.; 40 mg/kg i.p. (rat) (intravenous)