A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder

Barsuglia, Joseph P., Polanco, Martin, Palmer, Robert, Malcolm, Benjamin J., Kelmendi, Benjamin, Calvey, Tanya · 2018 · Progress in Brain Research

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SPECT case: Sequential ibogaine (17.9 mg/kg) + 5-MeO-DMT in veteran with AUD. Increased perfusion bilateral caudate/putamen/insula/cerebellum post-treatment. Alcohol cessation at 1 mo, partial return at 2 mo.

Dosing: 17.9 mg/kg ibogaine HCl (1550 mg total, split dose); 50 mg bufotoxin (~5–7 mg 5-MeO-DMT, vaporised) (oral)

Sample size: 1

Safety data present: ELECTROLYTE