Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice

Bading-Taika, Bayissi, Akinyeke, Tunde, Magana, Armando A., Choi, Jaewoo, Ouanesisouk, Michael, Torres, Eileen Ruth Samson, Lione, Lisa A., Maier, Claudia S., Bobe, Gerd, Raber, Jacob, Miranda, Cristobal L., Stevens, Jan F. · 2018 · Journal of Food Bioactives

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T. iboga root bark phytochemistry (30 alkaloids, 5 phenolics via LC-MS/MS) + metabolic/cognitive effects in HFD mice. Extract did not improve metabolic syndrome but reduced MCP-1. High-dose ibogaine impaired spatial memory.

Dosing: 0.83–2.07 mg ibogaine/kg/day (T. iboga root bark extract, dietary supplementation, 10 weeks, C57BL/6J mice) (oral)