Ibogaine induces juvenile-like plasticity and modulates functional and structural regulators of plasticity in the adult mouse visual cortex

Acuña, Alejo, Billeri, Federico, Totaro, Valentino, Carrera, Ignacio, Mesa, Juan M., Pizzorusso, Tommaso, Rossi, Francesco M. · 2025 · Research Square (Preprint)

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Single ibogaine dose (40mg/kg) restores juvenile-like plasticity in adult mouse visual cortex by reducing PNNs, PV interneurons, and vGAT—structural/inhibitory brakes on plasticity.

Sample size: 42