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Ibogaine in the 21st Century: Boosters, Tune-ups and Maintenance

Kroupa, Patrick K., Wells, Hattie · 2005 · MAPS Bulletin

Clinical protocols Case series high

AI-extracted · unverified · confirm at source

Landmark MAPS Bulletin introducing booster/maintenance protocols: 500-800mg follow-up doses during noribogaine window extend benefits, reduce relapse. Clean maintenance (drug-free) vs dirty maintenance (harm reduction) protocols.

Dosing: Flood 16–18 mg/kg; boosters/tune-ups 500–800 mg; clean maintenance 50 mg 2x/week + 100 mg every 45 days; dirty maintenance 25–50 mg/day oral (oral)

Sample size: 45

Contraindications: Concurrent opiate/opioid use at higher ibogaine doses — ibogaine potentiates analgesic effect, difference between 50 mg and 500 mg described as 'quite possibly fatal', Maintenance regimen beyond 20-25 days without break — jitteriness, sleep disturbance, overstimulation

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