Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics

Glue, Paul, Cape, Gavin, Tunnicliff, Donna, Lockhart, Michelle, Lam, Fred, Gray, Andrew, Hung, Noelyn, Hung, C. Tak, Harland, Sarah, Devane, Jane, Howes, John, Weis, Holger, Friedhoff, Lawrence · 2016 · The Journal of Clinical Pharmacology

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7-day methadone-to-morphine switch protocol: 27/27 completed with no dropouts. SR morphine at 5.2× methadone dose adequate. Methadone t½ 59h; 91% cleared in 7 days. No safety issues; no QTcF >500ms.

Dosing: SR morphine 4–5× methadone dose (mean 311 mg/day); clonidine 200 μg/day patch PRN (oral)

Sample size: 27