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Ibogaine and Subjective Experience: Transformative States and Psychopharmacotherapy in the Treatment of Opioid Use Disorder

Brown, Thomas K., Noller, Geoff E., Denenberg, Julie O. · 2019 · Journal of Psychoactive Drugs

Phenomenology Observational high

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43% of 42 ibogaine-treated OUD participants achieved complete mystical experience on SCQ; qualitative themes of confrontation, remorse, letting go, and transformation emerged

Dosing: 22.5 ± 10.1 mg/kg HCl (Mexico, n=26); 31.4 ± 7.6 mg/kg HCl (NZ, n=14); 9.9 ± 7.8 mg/kg HCl + 18.7 ± 17.3 mg/kg crude rootbark extract (Mexico, n=4) (oral)

Sample size: 44

Contraindications: Substance use disorders other than opioid dependence, Previous ibogaine treatment, Physical or psychosocial problems preventing compliance with study requirements

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